So, alright, let's see. Twilight Sparkle, Fluttershy, Apple Jack, Rainbow Dash, Rarity, and Pinkie Pie. Time to start shipping.
The most obvious pair to me is Rarity and Fluttershy. That just really WORKS in my mind. Classic /LL/ with Rarity as the older, loving, "Don't be afraid, let me teach you something new tonight" near-MILF of the pair, and Fluttershy acting as the naive, innocent, trusting, "I'm scared, but as long as it's you I'll do anything" younger of the two.
Apple Jack and Rainbow Dash are practically established canon, at this point. Rainbow is the spunk and the drive where Apple plays the reason and support. They are the classic, quintessential seme/uke pair.
Which, last but not least, leaves Twilight Sparkle and Pinkie Pie. And far from being the leftovers, I think these two actually work REALLY well together. Twilight gets annoyed with Pinkie sometimes (ok a lot of the time) but she also recognizes Pinkie's carefree, happy-go-lucky attitude and nigh (neigh?) unconditional love and trust as something that is sorely lacking in her life that she desperately needs. And secretly, deep down, she's a little jealous of Pinkie's ability to just be so...happy all the time. Even if she's not willing to trade in her intellect and wisdom for the blissful ignorance required to obtain it. On the other hand Pinkie thinks that, while Twilight can often be a real stick in the mud, she respects and admires her drive, intellect, and convictions. So instead of just giving up on her and brushing her off as someone who's no fun, she stands by her side in an effort to inject a little of that fun and fancy into Twilight's life. And she secretly really enjoys pushing her buttons and watching her reactions.
Man that ended up being way more detailed than I anticipated? What do you guys think? Any other takes or OTPs out there?